Analysis

The third-year wideout made an immediate impact when he connected with Joe Flacco for a 40-yard score on the Colts' first possession, but Pierce took a back seat to Josh Downs and Michael Pittman after that. Pierce put together a career-best campaign in 2024, posting a 37-824-7 line on 69 targets with a 22.3 yards per reception mark that led the NFL among players with at least 20 catches. While he's unlikely to ever see consistently high volume, Pierce proved he can be a dangerous deep threat regardless of who the Colts have under center, and a similar role in 2025 could lead to even better production if Anthony Richardson (back) takes a step forward in his development.

Analysis

The six grabs were a season high for Pierce, and it was the wideout's best performance since he posted a 3-134-1 line in Week 5 against the Jaguars -- a game which also featured Joe Flacco at QB for the Colts. Sunday's loss eliminated Indy from playoff contention, so even if Anthony Richardson (back/foot) is healthier, he could sit out Week 18 in favor of Flacco, which would make Pierce an appealing fantasy option in a rematch with Jacksonville.

Analysis

After missing Week 16 due to a concussion, Pierce logged a trio of full practices this week and is ready to return from his one-game absence. He's a low-percentage big-play specialist who leads the NFL in yards per catch (22.5) but has just 29 receptions on the season, turning them into 645 yards and five touchdowns. Pierce averages just 2.1 catches per contest.

Analysis

Pierce, who was inactive for Week 16 action, was estimated as a full participant Wednesday, so his continued full listing a day later bodes well for his chances of returning to the lineup Sunday against the Giants. Friday's injury report will confirm whether Pierce carries a Week 17 designation or is cleared to face New York, by way of having cleared the NFL's concussion protocol.

Analysis

Pierce was inactive for this past Sunday's win over the Titans, but his full listing on the team's initial Week 17 injury report is a good sign that he'll be available this weekend against the Giants. If the wideout can maintain full practice activity for the next two days in addition to gaining clearance from an independent neurologist, he should head into this Sunday's game without a designation.

Analysis

Pierce, who sustained a concussion during Week 15 action, didn't practice Wednesday or Thursday but participated in Friday's session, wearing a non-contact jersey, per Nate Atkins of The Indianapolis Star. However, with the wideout having been ruled out and targeting a potential return to action Sunday, Dec. 29 at the Giants, Adonai Mitchell figures to see added opportunities this weekend alongside fellow WRs Michael Pittman and Josh Downs.

Analysis

Pierce is officially being listed as a non-participant at practice for the second day in a row, but it appears he's making some amount of progress through the NFL's concussion protocol. The No. 3 wideout will need to gain full clearance, though, in order to be eligible to suit up for Sunday's game against the Titans. Adonai Mitchell will be in position to handle added opportunities behind Michael Pittman and Josh Downs if Pierce can't go.

Analysis

Pierce, who sustained a concussion during Sunday's loss to the Broncos, will have two more chances to practice this week before the Colts face off against the Titans. If Pierce is unable to play this weekend, Adonai Mitchell would be in line to see added opportunities alongside fellow wide receivers Michael Pittman and Josh Downs.

Analysis

Pierce was targeted on a deep ball by QB Anthony Richardson late in the first half, hitting the ground hard while attempting to haul in the pass and going directly to the locker room afterward. With a concussion confirmed for Pierce, he'll finish Week 16 with no catches on his four targets. Ashton Dulin (ankle) is inactive Sunday, so Adonai Mitchell and Anthony Gould are the tertiary WR options in the Colts offense behind Michael Pittman and Josh Downs.